Reaction Details Report a problem with these data
Target
Non-secretory ribonuclease
Ligand
BDBM50292713
Substrate
n/a
Meas. Tech.
ChEMBL_493882 (CHEMBL944253)
Ki
180±n/a nM
Citation
 Samanta, A; Leonidas, DD; Dasgupta, S; Pathak, T; Zographos, SE; Oikonomakos, NG Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation. J Med Chem 52:932-42 (2009) [PubMed]  Article 
Target
Name:
Non-secretory ribonuclease
Synonyms:
EDN | Eosinophil-derived neurotoxin (EDN) | Non-secretory ribonuclease | RNAS2_HUMAN | RNASE2 | RNAse 2 | RNS2
Type:
Protein
Mol. Mass.:
18364.09
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
161
Sequence:
MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
  
Inhibitor
Name:
BDBM50292713
Synonyms:
5'-phospho-2'-deoxyuridine 3-pyrophosphate (P'->5') adenosine 3'-phosphate | CHEMBL455775
Type:
Small organic molecule
Emp. Form.:
C19H25N7O14P2
Mol. Mass.:
637.3878
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H](C[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H]1O |r|
Structure:
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