Reaction Details Report a problem with these data
Target
Ribonuclease H1
Ligand
BDBM50292881
Substrate
n/a
Meas. Tech.
ChEMBL_494383 (CHEMBL941176)
IC50
50000±n/a nM
Citation
 Fuji, H; Urano, E; Futahashi, Y; Hamatake, M; Tatsumi, J; Hoshino, T; Morikawa, Y; Yamamoto, N; Komano, J Derivatives of 5-nitro-furan-2-carboxylic acid carbamoylmethyl ester inhibit RNase H activity associated with HIV-1 reverse transcriptase. J Med Chem 52:1380-7 (2010) [PubMed]  Article 
Target
Name:
Ribonuclease H1
Synonyms:
RNASEH1 | RNH1 | RNH1_HUMAN | RNase H1 | Ribonuclease H type II
Type:
Enzyme
Mol. Mass.:
32076.45
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
286
Sequence:
MSWLLFLAHRVALAALPCRRGSRGFGMFYAVRRGRKTGVFLTWNECRAQVDRFPAARFKKFATEDEAWAFVRKSASPEVSEGHENQHGQESEAKASKRLREPLDGDGHESAEPYAKHMKPSVEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED
  
Inhibitor
Name:
BDBM50292881
Synonyms:
5-nitro-furan-2-carboxylic acid [[4-(4-bromo-phenyl)-thiazol-2-yl]-(tetrahydro-furan-2-ylmethyl)-carbamoyl]-methyl ester | CHEMBL522795
Type:
Small organic molecule
Emp. Form.:
C21H18BrN3O7S
Mol. Mass.:
536.353
SMILES:
[O-][N+](=O)c1ccc(o1)C(=O)OCC(=O)N(CC1CCCO1)c1nc(cs1)-c1ccc(Br)cc1
Structure:
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