Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50293052
Substrate
n/a
Meas. Tech.
ChEMBL_519456 (CHEMBL950882)
IC50
35±n/a nM
Citation
Merritt, JR; Liu, J; Quadros, E; Morris, ML; Liu, R; Zhang, R; Jacob, B; Postelnek, J; Hicks, CM; Chen, W; Kimble, EF; Rogers, WL; O'Brien, L; White, N; Desai, H; Bansal, S; King, G; Ohlmeyer, MJ; Appell, KC; Webb, ML Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists. J Med Chem 52:1295-301 (2010) [PubMed] Article
More Info.:
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
Inhibitor
Name:
BDBM50293052
Synonyms:
(R)-N2-(4-Chlorobenzyl)-N1-[2-chloro-4-(trifluoromethyl)phenyl]-N2-methylpyrrolidine-1,2-dicarboxamide | CHEMBL473531
Type:
Small organic molecule
Emp. Form.:
C21H20Cl2F3N3O2
Mol. Mass.:
474.304
SMILES:
CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(cc1Cl)C(F)(F)F |r|