Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50119774
Substrate
n/a
Meas. Tech.
ChEMBL_497245 (CHEMBL1006198)
Ki
>100000±n/a nM
Citation
 Zhang, Z; Zheng, G; Pivavarchyk, M; Deaciuc, AG; Dwoskin, LP; Crooks, PA Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorg Med Chem Lett 18:5753-7 (2009) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50119774
Synonyms:
1,1'-(dodecane-1,12-diyl)bis(3-methylpyridinium)bromide | 1,12-di(3-methyl-1-pyridiniumyl)dodecane; with dibromide ions | 3-methyl-1-[6-(3-methylpyridinium-1-yl)dodecyl]pyridinium; Dibromide | CHEMBL54331 | N,N'-(1,12-dodecandiyl)-bis-pyridinium dibromide | N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide | N,N'-dodecane-1,12-diyl-bis-3-picoliniumdibromide | N,N'-dodecane-1,12-yl-bis-3-picolinium dibromide | N,N'-dodecylbis-picolinium bromide | mono(1,1'-(dodecane-1,12-diyl)bis(3-methylpyridinium))dibromide
Type:
Small organic molecule
Emp. Form.:
C24H38N2
Mol. Mass.:
354.5708
SMILES:
Cc1ccc[n+](CCCCCCCCCCCC[n+]2cccc(C)c2)c1
Structure:
Search PDB for entries with ligand similarity: