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Target
Beta-lactamase OXA-10
Ligand
BDBM50293713
Substrate
n/a
Meas. Tech.
ChEMBL_571868 (CHEMBL1034736)
pH
7±n/a
Ki
20000±n/a nM
Comments
extracted
Citation
 Beck, J; Vercheval, L; Bebrone, C; Herteg-Fernea, A; Lassaux, P; Marchand-Brynaert, J Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate. Bioorg Med Chem Lett 19:3593-7 (2009) [PubMed]  Article 
Target
Name:
Beta-lactamase OXA-10
Synonyms:
BLO10_PSEAI | bla | oxa10 | pse2
Type:
PROTEIN
Mol. Mass.:
29508.45
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_571868
Residue:
266
Sequence:
MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
  
Inhibitor
Name:
BDBM50293713
Synonyms:
CHEMBL553476 | Tribenzyl 2-(2-phenoxyacetamido)aminopropane-1,2,3-tricarboxylate
Type:
Small organic molecule
Emp. Form.:
C35H33NO8
Mol. Mass.:
595.6384
SMILES:
O=C(COc1ccccc1)NC(CC(=O)OCc1ccccc1)(CC(=O)OCc1ccccc1)C(=O)OCc1ccccc1
Structure:
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