Reaction Details Report a problem with these data
Target
Kinesin-like protein KIF3B
Ligand
BDBM50293768
Substrate
n/a
Meas. Tech.
ChEMBL_571922 (CHEMBL1035571)
IC50
>50000±n/a nM
Citation
 Lahue, BR; Ma, Y; Shipps, GW; Seghezzi, W; Herbst, R Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors. Bioorg Med Chem Lett 19:3405-9 (2009) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIF3B
Synonyms:
KIAA0359 | KIF3B | KIF3B_HUMAN
Type:
PROTEIN
Mol. Mass.:
85132.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_571922
Residue:
747
Sequence:
MSKLKSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLIIENFIPLEEKSKIMNRAFFDEEEDHWKLHPITRLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEARYRAENIVLLELDMPSRTTRDYEGPAIAPKVQAALDAALQDEDEIQVDASSFESTANKKSKARPKSGRKSGSSSSSSGTPASQLYPQSRGLVPK
  
Inhibitor
Name:
BDBM50293768
Synonyms:
4-(5-(pyrrolidine-1-carbonyl)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazol-2-ylamino)benzenesulfonamide | CHEMBL559435
Type:
Small organic molecule
Emp. Form.:
C26H24F3N5O3S
Mol. Mass.:
543.561
SMILES:
NS(=O)(=O)c1ccc(Nc2nc3cc(ccc3n2Cc2ccccc2C(F)(F)F)C(=O)N2CCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: