Reaction Details Report a problem with these data
Target
Interleukin-8
Ligand
BDBM50295271
Substrate
n/a
Meas. Tech.
ChEMBL_577736 (CHEMBL1052371)
IC50
600±n/a nM
Citation
 Sablone, MR; Cesta, MC; Moriconi, A; Aramini, A; Bizzarri, C; Di Giacinto, C; Di Bitondo, R; Gloaguen, I; Aschi, M; Crucianelli, M; Bertini, R; Allegretti, M Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett 19:4026-30 (2009) [PubMed]  Article 
Target
Name:
Interleukin-8
Synonyms:
CXCL8 | IL8 | IL8_HUMAN | MDNCF-a | interleukin 8 precursor
Type:
PROTEIN
Mol. Mass.:
11104.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_577736
Residue:
99
Sequence:
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
  
Inhibitor
Name:
BDBM50295271
Synonyms:
2-{2-[(2,6-Dichlorophenyl)amino]phenyl}-N-(2,6-dimethylphenyl)propanamide | CHEMBL559389
Type:
Small organic molecule
Emp. Form.:
C23H22Cl2N2O
Mol. Mass.:
413.34
SMILES:
CC(C(=O)Nc1c(C)cccc1C)c1ccccc1Nc1c(Cl)cccc1Cl
Structure:
Search PDB for entries with ligand similarity: