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Target
Interleukin-8
Ligand
BDBM50295274
Substrate
n/a
Meas. Tech.
ChEMBL_577736 (CHEMBL1052371)
IC50
500±n/a nM
Citation
 Sablone, MR; Cesta, MC; Moriconi, A; Aramini, A; Bizzarri, C; Di Giacinto, C; Di Bitondo, R; Gloaguen, I; Aschi, M; Crucianelli, M; Bertini, R; Allegretti, M Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett 19:4026-30 (2009) [PubMed]  Article 
Target
Name:
Interleukin-8
Synonyms:
CXCL8 | IL8 | IL8_HUMAN | MDNCF-a | interleukin 8 precursor
Type:
PROTEIN
Mol. Mass.:
11104.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_577736
Residue:
99
Sequence:
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
  
Inhibitor
Name:
BDBM50295274
Synonyms:
2-(2-(2,6-dichloro-3-methylphenylamino)phenyl)acetic acid | CHEMBL541236
Type:
Small organic molecule
Emp. Form.:
C15H13Cl2NO2
Mol. Mass.:
310.175
SMILES:
Cc1ccc(Cl)c(Nc2ccccc2CC(O)=O)c1Cl
Structure:
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