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Target
Histone deacetylase 1
Ligand
BDBM50114826
Substrate
n/a
Meas. Tech.
ChEMBL_579921 (CHEMBL1056354)
IC50
15±n/a nM
Citation
 Chen, Y; Li, H; Tang, W; Zhu, C; Jiang, Y; Zou, J; Yu, Q; You, Q 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem 44:2868-76 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50114826
Synonyms:
8-(4-Methoxy-phenyl)-8-oxo-octanoic acid hydroxyamide | CHEMBL95835 | N-hydroxy-8-(4-methoxyphenyl)-8-oxooctanamide
Type:
Small organic molecule
Emp. Form.:
C15H21NO4
Mol. Mass.:
279.3315
SMILES:
COc1ccc(cc1)C(=O)CCCCCCC(=O)NO
Structure:
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