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Target
Histone deacetylase 1
Ligand
BDBM50114821
Substrate
n/a
Meas. Tech.
ChEMBL_579921 (CHEMBL1056354)
IC50
9.5±n/a nM
Citation
 Chen, Y; Li, H; Tang, W; Zhu, C; Jiang, Y; Zou, J; Yu, Q; You, Q 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem 44:2868-76 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50114821
Synonyms:
8-Oxo-8-(4-piperidin-1-yl-phenyl)-octanoic acid hydroxyamide | CHEMBL99877 | N-hydroxy-8-oxo-8-(4-(piperidin-1-yl)phenyl)octanamide
Type:
Small organic molecule
Emp. Form.:
C19H28N2O3
Mol. Mass.:
332.4372
SMILES:
ONC(=O)CCCCCCC(=O)c1ccc(cc1)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: