Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma
Ligand
BDBM50296049
Substrate
n/a
Meas. Tech.
ChEMBL_579374 (CHEMBL1063215)
IC50
40±n/a nM
Citation
 Sun, W; Carroll, PJ; Soprano, DR; Canney, DJ Identification of a chromone-based retinoid containing a polyolefinic side chain via facile synthetic routes. Bioorg Med Chem Lett 19:4339-42 (2009) [PubMed]  Article 
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
  
Inhibitor
Name:
BDBM50296049
Synonyms:
(2E,4E)-2,4-dimethyl-5-(6,6,9,9-tetramethyl-4-oxo-6,7,8,9-tetrahydro-4H-benzo[g]chromen-3-yl)penta-2,4-dienoic acid | CHEMBL550796
Type:
Small organic molecule
Emp. Form.:
C24H28O4
Mol. Mass.:
380.4767
SMILES:
C\C(\C=C(/C)C(O)=O)=C/c1coc2cc3c(cc2c1=O)C(C)(C)CCC3(C)C
Structure:
Search PDB for entries with ligand similarity: