Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50296386
Substrate
n/a
Meas. Tech.
ChEMBL_580553 (CHEMBL1053999)
IC50
4112±n/a nM
Citation
 Lakshminarayana, N; Rajendra Prasad, Y; Gharat, L; Thomas, A; Ravikumar, P; Narayanan, S; Srinivasan, CV; Gopalan, B Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents. Eur J Med Chem 44:3147-57 (2009) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50296386
Synonyms:
(3S)-7-{4-[(4R)-1,3-Dithian-4-yl]butylcarboxamido}-isochroman-3-carboxylic acid | CHEMBL551671
Type:
Small organic molecule
Emp. Form.:
C19H25NO4S2
Mol. Mass.:
395.536
SMILES:
OC(=O)[C@@H]1Cc2ccc(NC(=O)CCCC[C@@H]3CCSCS3)cc2CO1 |r|
Structure:
Search PDB for entries with ligand similarity: