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Target
Acid-sensing ion channel 3
Ligand
BDBM50296576
Substrate
n/a
Meas. Tech.
ChEMBL_582093 (CHEMBL1061604)
IC50
51000±n/a nM
Citation
 Kuduk, SD; Chang, RK; Wai, JM; Di Marco, CN; Cofre, V; DiPardo, RM; Cook, SP; Cato, MJ; Jovanovska, A; Urban, MO; Leitl, M; Spencer, RH; Kane, SA; Hartman, GD; Bilodeau, MT Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3). Bioorg Med Chem Lett 19:4059-63 (2009) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 3
Synonyms:
ACCN3 | ASIC3 | ASIC3_HUMAN | Amiloride-sensitive cation channel 3 | SLNAC1 | TNAC1
Type:
PROTEIN
Mol. Mass.:
58910.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_757561
Residue:
531
Sequence:
MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL
  
Inhibitor
Name:
BDBM50296576
Synonyms:
2-(3-chloro-5-methylphenyl)-1H-indole-5-carboximidamide | CHEMBL563745
Type:
Small organic molecule
Emp. Form.:
C16H14ClN3
Mol. Mass.:
283.755
SMILES:
Cc1cc(Cl)cc(c1)-c1cc2cc(ccc2[nH]1)C(N)=N
Structure:
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