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Target
Cyclin-dependent kinase 2
Ligand
BDBM50297272
Substrate
n/a
Meas. Tech.
ChEMBL_582880 (CHEMBL1051861)
IC50
816000±n/a nM
Citation
 Aubry, C; Wilson, AJ; Emmerson, D; Murphy, E; Chan, YY; Dickens, MP; García, MD; Jenkins, PR; Mahale, S; Chaudhuri, B Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1. Bioorg Med Chem 17:6073-84 (2009) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50297272
Synonyms:
1-(5-Fluoro-2,3-dihydro-indol-1-yl)-2-(5-fluoro-1Hindol-3-yl)-ethane-1,2-dione | CHEMBL559683
Type:
Small organic molecule
Emp. Form.:
C18H12F2N2O2
Mol. Mass.:
326.2969
SMILES:
Fc1ccc2N(CCc2c1)C(=O)C(=O)c1c[nH]c2ccc(F)cc12
Structure:
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