Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50297368
Substrate
n/a
Meas. Tech.
ChEMBL_583250 (CHEMBL1055805)
Ki
1.58±n/a nM
Citation
 Covel, JA; Santora, VJ; Smith, JM; Hayashi, R; Gallardo, C; Weinhouse, MI; Ibarra, JB; Schultz, JA; Park, DM; Estrada, SA; Hofilena, BJ; Pulley, MD; Smith, BM; Ren, A; Suarez, M; Frazer, J; Edwards, J; Hauser, EK; Lorea, J; Semple, G; Grottick, AJ Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity. J Med Chem 52:5603-11 (2009) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50297368
Synonyms:
4-{4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphenyl-4-sulfonyl}-morpholine | CHEMBL564380
Type:
Small organic molecule
Emp. Form.:
C23H30N2O3S
Mol. Mass.:
414.561
SMILES:
C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 |r|
Structure:
Search PDB for entries with ligand similarity: