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Target
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Ligand
BDBM50298243
Substrate
n/a
Meas. Tech.
ChEMBL_588425 (CHEMBL1039465)
Ki
200±n/a nM
Citation
 Henry, O; Lopez-Gallego, F; Agger, SA; Schmidt-Dannert, C; Sen, S; Shintani, D; Cornish, K; Distefano, MD A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes. Bioorg Med Chem 17:4797-805 (2009) [PubMed]  Article 
Target
Name:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
CAAX farnesyltransferase subunit alpha | FNTA_YEAST | FTase-alpha | Farnesyltransferase | GGTase-I-alpha | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | RAM2 | Ras proteins prenyltransferase subunit alpha | Type I protein geranyl-geranyltransferase subunit alpha
Type:
PROTEIN
Mol. Mass.:
37495.69
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_588425
Residue:
316
Sequence:
MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIIDVAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKLHPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSAWTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSKVVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKYDPIRKNLWHHKINNLN
  
Inhibitor
Name:
BDBM50298243
Synonyms:
(2E,6E)-8-(2-diazo-3,3,3-trifluoropropanoyloxy)-3,7-dimethylocta-2,6-dienyl diphosphate | CHEMBL572404
Type:
Small organic molecule
Emp. Form.:
C13H19F3N2O9P2
Mol. Mass.:
466.2407
SMILES:
C\C(CC\C=C(/C)COC(=O)[C-]([N+]#N)C(F)(F)F)=C/COP(O)(=O)OP(O)(O)=O
Structure:
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