Reaction Details Report a problem with these data
Target
Elongation of very long chain fatty acids protein 6
Ligand
BDBM50298969
Substrate
n/a
Meas. Tech.
ChEMBL_588224 (CHEMBL1043978)
IC50
120±n/a nM
Citation
Sasaki, T; Nagase, T; Takahashi, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. Bioorg Med Chem 17:5639-47 (2009) [PubMed] Article
More Info.:
Target
Name:
Elongation of very long chain fatty acids protein 6
Synonyms:
ELOV6_HUMAN | ELOVL6 | FACE | LCE
Type:
PROTEIN
Mol. Mass.:
31392.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_572238
Residue:
265
Sequence:
MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMVYILMTKGLKQSVCDQGFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVVNYLVFCWMQHDQCHSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKMRKTTKAE
Inhibitor
Name:
BDBM50298969
Synonyms:
(1R*,4S*,6R*)-(+/-)-N-[4-(Propan-2-yloxy)phenyl]-2-(pyridin-2-ylsulfonyl)-2-azabicyclo[2.2.2]octane-6-carboxamide | CHEMBL579051
Type:
Small organic molecule
Emp. Form.:
C22H27N3O4S
Mol. Mass.:
429.532
SMILES:
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(C3)S(=O)(=O)c2ccccn2)cc1 |r,TLB:9:11:18.17:14.15,THB:19:17:12.11:14.15|