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Target
Adenosine receptor A3
Ligand
BDBM50299699
Substrate
n/a
Meas. Tech.
ChEMBL_588680 (CHEMBL1056090)
Ki
3.8±n/a nM
Citation
 Volpini, R; Buccioni, M; Dal Ben, D; Lambertucci, C; Lammi, C; Marucci, G; Ramadori, AT; Klotz, KN; Cristalli, G Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor. J Med Chem 52:7897-900 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50299699
Synonyms:
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(methoxyamino)-2-(phenylethynyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | CHEMBL573030
Type:
Small organic molecule
Emp. Form.:
C19H19N5O5
Mol. Mass.:
397.3847
SMILES:
CONc1nc(nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)C#Cc1ccccc1 |r|
Structure:
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