Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50300593
Substrate
n/a
Meas. Tech.
ChEMBL_588968 (CHEMBL1056163)
EC50
10±n/a nM
Citation
 Iino, T; Sasaki, Y; Bamba, M; Mitsuya, M; Ohno, A; Kamata, K; Hosaka, H; Maruki, H; Futamura, M; Yoshimoto, R; Ohyama, S; Sasaki, K; Chiba, M; Ohtake, N; Nagata, Y; Eiki, J; Nishimura, T Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators. Bioorg Med Chem Lett 19:5531-8 (2009) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50300593
Synonyms:
3-methyl-2-(4-(1-methyl-1H-pyrazol-3-ylamino)quinazolin-6-yloxy)benzonitrile | CHEMBL572840
Type:
Small organic molecule
Emp. Form.:
C20H16N6O
Mol. Mass.:
356.3806
SMILES:
Cc1cccc(C#N)c1Oc1ccc2ncnc(Nc3ccn(C)n3)c2c1
Structure:
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