Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50300675
Substrate
n/a
Meas. Tech.
ChEMBL_589223 (CHEMBL1041217)
Ki
1±n/a nM
Citation
 Mesquida, N; López-Pérez, S; Dinarès, I; Frigola, J; Mercè, R; Holenz, J; Pérez, R; Burgueño, J; Alcalde, E Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists. J Med Chem 52:6153-7 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50300675
Synonyms:
2-(1-(5-(phenylsulfonamido)-1H-indol-3-yl)ethylidene)hydrazinecarboximidamide | CHEMBL573982
Type:
Small organic molecule
Emp. Form.:
C17H18N6O2S
Mol. Mass.:
370.429
SMILES:
CC(=NN=C(N)N)c1c[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 |w:2.2,(28.57,2.48,;29.6,1.34,;31.11,1.66,;31.59,3.12,;33.09,3.44,;33.57,4.91,;34.12,2.3,;29.13,-.13,;30.04,-1.38,;29.13,-2.64,;27.66,-2.16,;26.32,-2.93,;24.99,-2.16,;24.99,-.62,;23.66,.15,;23.65,1.69,;23.64,3.23,;24.97,1.68,;22.11,1.7,;21.36,3.04,;19.82,3.05,;19.04,1.72,;19.81,.38,;21.35,.38,;26.31,.15,;27.65,-.61,)|
Structure:
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