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Target
High affinity immunoglobulin gamma Fc receptor I
Ligand
BDBM50303805
Substrate
n/a
Meas. Tech.
ChEMBL_594757 (CHEMBL1039867)
IC50
2900±n/a nM
Citation
 Zacharie, B; Abbott, SD; Bienvenu, JF; Cameron, AD; Cloutier, J; Duceppe, JS; Ezzitouni, A; Fortin, D; Houde, K; Lauzon, C; Moreau, N; Perron, V; Wilb, N; Asselin, M; Doucet, A; Fafard, ME; Gaudreau, D; Grouix, B; Sarra-Bournet, F; St-Amant, N; Gagnon, L; Penney, CL 2,4,6-trisubstituted triazines as protein a mimetics for the treatment of autoimmune diseases. J Med Chem 53:1138-45 (2010) [PubMed]  Article 
Target
Name:
High affinity immunoglobulin gamma Fc receptor I
Synonyms:
FCG1 | FCGR1 | FCGR1A | FCGR1_HUMAN | IGFR1
Type:
PROTEIN
Mol. Mass.:
42639.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446762
Residue:
374
Sequence:
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
  
Inhibitor
Name:
BDBM50303805
Synonyms:
2-(4-(4-(4-(4-aminophenethylamino)-6-(3-aminophenylamino)-1,3,5-triazin-2-ylamino)phenethylamino)-6-(3-aminophenylamino)-1,3,5-triazin-2-ylamino)ethanol | CHEMBL570394
Type:
Small organic molecule
Emp. Form.:
C36H41N15O
Mol. Mass.:
699.8106
SMILES:
Nc1ccc(CCNc2nc(Nc3ccc(CCNc4nc(NCCO)nc(Nc5cccc(N)c5)n4)cc3)nc(Nc3cccc(N)c3)n2)cc1
Structure:
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