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Target
Hypoxia-inducible factor 1-alpha inhibitor
Ligand
BDBM50304613
Substrate
n/a
Meas. Tech.
ChEMBL_606822 (CHEMBL1068586)
IC50
48600±n/a nM
Citation
 Ko, S; Lee, MK; Shin, D; Park, H Structure-based virtual screening approach to the discovery of novel inhibitors of factor-inhibiting HIF-1: identification of new chelating groups for the active-site ferrous ion. Bioorg Med Chem 17:7769-74 (2009) [PubMed]  Article 
Target
Name:
Hypoxia-inducible factor 1-alpha inhibitor
Synonyms:
FIH1 | HIF1AN | HIF1N_HUMAN | Hypoxia-inducible factor 1 (FIH) | Hypoxia-inducible factor 1-alpha inhibitor
Type:
Enzyme
Mol. Mass.:
40278.92
Organism:
Homo sapiens (Human)
Description:
Q9NWT6
Residue:
349
Sequence:
MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
  
Inhibitor
Name:
BDBM50304613
Synonyms:
CHEMBL593127 | N-(benzo[c][1,2,5]oxadiazol-4-yl)-3-(5-(3-(furan-2-yl)allylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanamide
Type:
Small organic molecule
Emp. Form.:
C19H14N4O4S2
Mol. Mass.:
426.469
SMILES:
O=C(CCN1C(=S)S\C(=C\C=C\c2ccco2)C1=O)Nc1cccc2nonc12
Structure:
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