Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50305106
Substrate
n/a
Meas. Tech.
ChEMBL_603081 (CHEMBL1048564)
Ki
6±n/a nM
Citation
 Shen, Z; Siva Ramamoorthy, P; Hatzenbuhler, NT; Evrard, DA; Childers, W; Harrison, BL; Chlenov, M; Hornby, G; Smith, DL; Sullivan, KM; Schechter, LE; Andree, TH Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT(1A) receptor and the serotonin transporter. Bioorg Med Chem Lett 20:222-7 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50305106
Synonyms:
(+)-8-((cyclopropylmethyl)(3-(5-fluoro-1H-indol-3-yl)propyl)amino)-2,3,8,9-tetrahydropyrano[3,2-e]isoindol-1(7H)-one | (-)-8-((cyclopropylmethyl)(3-(5-fluoro-1H-indol-3-yl)propyl)amino)-2,3,8,9-tetrahydropyrano[3,2-e]isoindol-1(7H)-one | CHEMBL607419 | Rac-8-((cyclopropylmethyl)(3-(5-fluoro-1H-indol-3-yl)propyl)amino)-2,3,8,9-tetrahydropyrano[3,2-e]isoindol-1(7H)-one
Type:
Small organic molecule
Emp. Form.:
C26H28FN3O2
Mol. Mass.:
433.5178
SMILES:
Fc1ccc2[nH]cc(CCCN(CC3CC3)C3COc4ccc5CNC(=O)c5c4C3)c2c1
Structure:
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