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Target
Kinesin-like protein KIF11
Ligand
BDBM50305229
Substrate
n/a
Meas. Tech.
ChEMBL_603302 (CHEMBL1037992)
IC50
8100±n/a nM
Citation
 Barsanti, PA; Wang, W; Ni, ZJ; Duhl, D; Brammeier, N; Martin, E; Bussiere, D; Walter, AO The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5. Bioorg Med Chem Lett 20:157-60 (2010) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIF11
Synonyms:
EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin Spindle Protein Eg5 | Kinesin-like protein 1 | TRIP5 | kinesin spindle protein
Type:
PROTEIN
Mol. Mass.:
119138.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1457426
Residue:
1056
Sequence:
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
  
Inhibitor
Name:
BDBM50305229
Synonyms:
(2R)-2-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-methylbutan-1-one | CHEMBL589392
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O2
Mol. Mass.:
397.898
SMILES:
CC(C)[C@@H](N)C(=O)N1CCc2c([nH]c3ccc(Cl)cc23)C1c1cccc(O)c1 |r|
Structure:
Search PDB for entries with ligand similarity: