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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50305569
Substrate
n/a
Meas. Tech.
ChEMBL_604516 (CHEMBL1074686)
EC50
19000±n/a nM
Citation
 Kitas, E; Mohr, P; Kuhn, B; Hebeisen, P; Wessel, HP; Haap, W; Ruf, A; Benz, J; Joseph, C; Huber, W; Sanchez, RA; Paehler, A; Benardeau, A; Gubler, M; Schott, B; Tozzo, E Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes. Bioorg Med Chem Lett 20:594-9 (2010) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_MOUSE | Fbp | Fbp1 | Fbp3
Type:
PROTEIN
Mol. Mass.:
36912.07
Organism:
Mus musculus
Description:
ChEMBL_748173
Residue:
338
Sequence:
MANHAPFETDISTLTRFVMEQGRKAQGTGELTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEENTNAIIIEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSEKDALQPGRDLVAAGYALYGSATMLVLAMDCGVNCFMLDPSIGEFIMVDRDVKMKKKGNIYSLNEGYAKDFDPAINEYLQRKKFPPDGSAPYGARYVGSMVADIHRTLVYGGIFLYPANKKSPSGKLRLLYECNPIAYVMEKAGGLATTGDKDILDIVPTEIHQKAPVVMGSSEDVQEFLEIYRKHKAK
  
Inhibitor
Name:
BDBM50305569
Synonyms:
CHEMBL590597 | N-(5-bromothiazol-2-ylcarbamoyl)-5-(4-methoxy-2-methylphenyl)-4-methylthiophene-2-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C17H16BrN3O4S3
Mol. Mass.:
502.426
SMILES:
COc1ccc(-c2sc(cc2C)S(=O)(=O)NC(=O)Nc2ncc(Br)s2)c(C)c1
Structure:
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