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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50305587
Substrate
n/a
Meas. Tech.
ChEMBL_604516 (CHEMBL1074686)
EC50
32000±n/a nM
Citation
Kitas, E; Mohr, P; Kuhn, B; Hebeisen, P; Wessel, HP; Haap, W; Ruf, A; Benz, J; Joseph, C; Huber, W; Sanchez, RA; Paehler, A; Benardeau, A; Gubler, M; Schott, B; Tozzo, E Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes. Bioorg Med Chem Lett 20:594-9 (2010) [PubMed] Article
More Info.:
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_MOUSE | Fbp | Fbp1 | Fbp3
Type:
PROTEIN
Mol. Mass.:
36912.07
Organism:
Mus musculus
Description:
ChEMBL_748173
Residue:
338
Sequence:
MANHAPFETDISTLTRFVMEQGRKAQGTGELTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEENTNAIIIEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSEKDALQPGRDLVAAGYALYGSATMLVLAMDCGVNCFMLDPSIGEFIMVDRDVKMKKKGNIYSLNEGYAKDFDPAINEYLQRKKFPPDGSAPYGARYVGSMVADIHRTLVYGGIFLYPANKKSPSGKLRLLYECNPIAYVMEKAGGLATTGDKDILDIVPTEIHQKAPVVMGSSEDVQEFLEIYRKHKAK
Inhibitor
Name:
BDBM50305587
Synonyms:
CHEMBL589137 | N-(5-bromothiazol-2-ylcarbamoyl)-3-ethylbenzenesulfonamide | N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3-ethylbenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C12H12BrN3O3S2
Mol. Mass.:
390.276
SMILES:
CCc1cccc(c1)S(=O)(=O)NC(=O)Nc1ncc(Br)s1