Reaction Details Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50305595
Substrate
n/a
Meas. Tech.
ChEMBL_604516 (CHEMBL1074686)
EC50
15000±n/a nM
Citation
 Kitas, E; Mohr, P; Kuhn, B; Hebeisen, P; Wessel, HP; Haap, W; Ruf, A; Benz, J; Joseph, C; Huber, W; Sanchez, RA; Paehler, A; Benardeau, A; Gubler, M; Schott, B; Tozzo, E Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes. Bioorg Med Chem Lett 20:594-9 (2010) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_MOUSE | Fbp | Fbp1 | Fbp3
Type:
PROTEIN
Mol. Mass.:
36912.07
Organism:
Mus musculus
Description:
ChEMBL_748173
Residue:
338
Sequence:
MANHAPFETDISTLTRFVMEQGRKAQGTGELTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEENTNAIIIEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSEKDALQPGRDLVAAGYALYGSATMLVLAMDCGVNCFMLDPSIGEFIMVDRDVKMKKKGNIYSLNEGYAKDFDPAINEYLQRKKFPPDGSAPYGARYVGSMVADIHRTLVYGGIFLYPANKKSPSGKLRLLYECNPIAYVMEKAGGLATTGDKDILDIVPTEIHQKAPVVMGSSEDVQEFLEIYRKHKAK
  
Inhibitor
Name:
BDBM50305595
Synonyms:
CHEMBL591317 | N-(7-chloro-4-methoxybenzo[d]thiazol-2-ylcarbamoyl)-5-(2-hydroxyethyl)-4-methylthiophene-2-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C16H16ClN3O5S3
Mol. Mass.:
461.963
SMILES:
COc1ccc(Cl)c2sc(NC(=O)NS(=O)(=O)c3cc(C)c(CCO)s3)nc12
Structure:
Search PDB for entries with ligand similarity: