Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50308522
Substrate
n/a
Meas. Tech.
ChEMBL_613431 (CHEMBL1069542)
IC50
42±n/a nM
Citation
 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs. Bioorg Med Chem 18:2275-84 (2010) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase
Type:
Enzyme
Mol. Mass.:
32035.18
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
289
Sequence:
MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
  
Inhibitor
Name:
BDBM50308522
Synonyms:
9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-deazaguanine | CHEMBL591019
Type:
Small organic molecule
Emp. Form.:
C17H27F2N4O4P
Mol. Mass.:
420.3912
SMILES:
CCOP(=O)(OCC)C(F)(F)CCCCCCc1c[nH]c2c1nc(N)[nH]c2=O
Structure:
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