Reaction Details Report a problem with these data
Target
Secreted frizzled-related protein 1
Ligand
BDBM50308694
Substrate
n/a
Meas. Tech.
ChEMBL_607291 (CHEMBL1072833)
IC50
130±n/a nM
Citation
 Moore, WJ; Kern, JC; Bhat, R; Bodine, PV; Fukyama, S; Krishnamurthy, G; Magolda, RL; Pitts, K; Stauffer, B; Trybulski, EJ Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg Med Chem 18:190-201 (2010) [PubMed]  Article 
Target
Name:
Secreted frizzled-related protein 1
Synonyms:
FRP | FRP1 | SARP2 | SFRP1 | SFRP1_HUMAN
Type:
PROTEIN
Mol. Mass.:
35404.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1363191
Residue:
314
Sequence:
MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK
  
Inhibitor
Name:
BDBM50308694
Synonyms:
CHEMBL590478 | N-{1-[(6-Morpholin-4-ylpyridin-3-yl)carbonyl]piperidin-4-yl}-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C28H29F3N4O6S2
Mol. Mass.:
638.678
SMILES:
FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)c1ccc(nc1)N1CCOCC1)S(=O)(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: