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Target
Phospholipase A-2-activating protein
Ligand
BDBM46053
Substrate
n/a
Meas. Tech.
ChEMBL_610122 (CHEMBL1074487)
IC50
5800±n/a nM
Citation
 Lanier, M; Sergienko, E; Simão, AM; Su, Y; Chung, T; Millán, JL; Cashman, JR Design and synthesis of selective inhibitors of placental alkaline phosphatase. Bioorg Med Chem 18:573-9 (2010) [PubMed]  Article 
Target
Name:
Phospholipase A-2-activating protein
Synonyms:
PLAA | PLAP | PLAP_HUMAN
Type:
PROTEIN
Mol. Mass.:
87154.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_610122
Residue:
795
Sequence:
MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTESEDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGEKVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPGSSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEAVTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILWKAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSEPAKVSECCRFILNLL
  
Inhibitor
Name:
BDBM46053
Synonyms:
1-(3,4-dihydroxyphenyl)-2-(4-methyl-1-imidazolyl)ethanone;hydrochloride | 1-(3,4-dihydroxyphenyl)-2-(4-methylimidazol-1-yl)ethanone;hydrochloride | 1-[3,4-bis(oxidanyl)phenyl]-2-(4-methylimidazol-1-yl)ethanone;hydrochloride | CHEMBL597027 | MLS-0315855.0001 | cid_25067497
Type:
Small organic molecule
Emp. Form.:
C12H12N2O3
Mol. Mass.:
232.2353
SMILES:
Cc1cn(CC(=O)c2ccc(O)c(O)c2)cn1
Structure:
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