Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50309940
Substrate
n/a
Meas. Tech.
ChEMBL_612155 (CHEMBL1073577)
IC50
234±n/a nM
Citation
 Kim, SH; Ramu, R; Kwon, SW; Lee, SH; Kim, CH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Ha, DC; Cheon, HG; Kim, KY; Ahn, JH Discovery of cyclicsulfonamide derivatives as 11beta-hydroxysteroid dehydrogenase 1 inhibitors. Bioorg Med Chem Lett 20:1065-9 (2010) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50309940
Synonyms:
(4-Hydroxy-1,1-dioxo-2-phenethyl-1,2-dihydro-1lambda*6*-benzo[e][1,2]thiazin-3-yl)-phenyl-methanone | CHEMBL592717
Type:
Small organic molecule
Emp. Form.:
C23H19NO4S
Mol. Mass.:
405.466
SMILES:
OC1=C(N(CCc2ccccc2)S(=O)(=O)c2ccccc12)C(=O)c1ccccc1 |t:1|
Structure:
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