Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50309941
Substrate
n/a
Meas. Tech.
ChEMBL_612155 (CHEMBL1073577)
IC50
740±n/a nM
Citation
 Kim, SH; Ramu, R; Kwon, SW; Lee, SH; Kim, CH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Ha, DC; Cheon, HG; Kim, KY; Ahn, JH Discovery of cyclicsulfonamide derivatives as 11beta-hydroxysteroid dehydrogenase 1 inhibitors. Bioorg Med Chem Lett 20:1065-9 (2010) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50309941
Synonyms:
CHEMBL592725 | Trifluoro-methanesulfonic acid 3-benzoyl-1,1-dioxo-2-(2-oxo-2-phenyl-ethyl)-1,2-dihydro-1lambda*6*-benzo[e][1,2]thiazin-4-yl ester
Type:
Small organic molecule
Emp. Form.:
C24H16F3NO7S2
Mol. Mass.:
551.512
SMILES:
FC(F)(F)S(=O)(=O)OC1=C(N(CC(=O)c2ccccc2)S(=O)(=O)c2ccccc12)C(=O)c1ccccc1 |t:8|
Structure:
Search PDB for entries with ligand similarity: