Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50310057
Substrate
n/a
Meas. Tech.
ChEMBL_612189 (CHEMBL1074127)
IC50
5.14±n/a nM
Citation
 Seo, HJ; Kim, MJ; Lee, SH; Lee, SH; Jung, ME; Kim, MS; Ahn, K; Kim, J; Lee, J Synthesis and structure-activity relationship of 1,2,4-triazole-containing diarylpyrazolyl carboxamide as CB1 cannabinoid receptor-ligand. Bioorg Med Chem 18:1149-62 (2010) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50310057
Synonyms:
4-((1H-1,2,4-Triazol-1-yl)methyl)-1-(2-chlorophenyl)-5-(4-chlorophenyl)-N-(1-(trifluoromethyl)cyclobutyl)-1H-pyrazole-3-carboxamide | CHEMBL605358
Type:
Small organic molecule
Emp. Form.:
C24H19Cl2F3N6O
Mol. Mass.:
535.348
SMILES:
FC(F)(F)C1(CCC1)NC(=O)c1nn(c(c1Cn1cncn1)-c1ccc(Cl)cc1)-c1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: