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Target
Mu-type opioid receptor
Ligand
BDBM50312857
Substrate
n/a
Meas. Tech.
ChEMBL_615875 (CHEMBL1102709)
Ki
344±n/a nM
Citation
 Ballet, S; Marczak, ED; Feytens, D; Salvadori, S; Sasaki, Y; Abell, AD; Lazarus, LH; Balboni, G; Tourwé, D Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds. Bioorg Med Chem Lett 20:1610-3 (2010) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50312857
Synonyms:
(2S,2'S)-N,N'-((4S,4'S)-2,2'-(2,2'-(ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(3-oxo-1,2,3,4,5,10-hexahydroazepino[3,4-b]indole-4,2-diyl))bis(2-(dimethylamino)-3-(4-hydroxy-2,6-dimethylphenyl)propanamide) | CHEMBL1076739
Type:
Small organic molecule
Emp. Form.:
C56H68N10O8
Mol. Mass.:
1009.2013
SMILES:
CN(C)[C@@H](Cc1c(C)cc(O)cc1C)C(=O)N[C@H]1Cc2c(CN(CC(=O)NCCNC(=O)CN3Cc4[nH]c5ccccc5c4C[C@H](NC(=O)[C@H](Cc4c(C)cc(O)cc4C)N(C)C)C3=O)C1=O)[nH]c1ccccc21 |r|
Structure:
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