Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50313078
Substrate
n/a
Meas. Tech.
ChEMBL_616400 (CHEMBL1100686)
Ki
6±n/a nM
Citation
 Eastwood, P; Gonzalez, J; Paredes, S; Fonquerna, S; Cardús, A; Alonso, JA; Nueda, A; Domenech, T; Reinoso, RF; Vidal, B Discovery of potent and selective bicyclic A(2B) adenosine receptor antagonists via bioisosteric amide replacement. Bioorg Med Chem Lett 20:1634-7 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50313078
Synonyms:
5-(furan-2-yl)-6-(pyrimidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one | CHEMBL1076563
Type:
Small organic molecule
Emp. Form.:
C14H9N5O2
Mol. Mass.:
279.2536
SMILES:
O=c1[nH]c2cc(-c3ccncn3)c(nc2[nH]1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: