Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM50313168
Substrate
n/a
Meas. Tech.
ChEMBL_616817 (CHEMBL1099401)
IC50
21±n/a nM
Citation
 Sifferlen, T; Boss, C; Cottreel, E; Koberstein, R; Gude, M; Aissaoui, H; Weller, T; Gatfield, J; Brisbare-Roch, C; Jenck, F Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonists. Bioorg Med Chem Lett 20:1539-42 (2010) [PubMed]  Article 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM50313168
Synonyms:
2-(1-ethyl-3-methyl-4-(2-methylphenethyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-N-methyl-2-phenylacetamide | CHEMBL1082024
Type:
Small organic molecule
Emp. Form.:
C27H34N4O
Mol. Mass.:
430.5851
SMILES:
CCn1nc(C)c2C(CCc3ccccc3C)N(CCc12)C(C(=O)NC)c1ccccc1
Structure:
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