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Target
Metacaspase-2
Ligand
BDBM14297
Substrate
n/a
Meas. Tech.
ChEMBL_614949 (CHEMBL1116826)
IC50
1600±n/a nM
Citation
Berg, M; Van der Veken, P; Joossens, J; Muthusamy, V; Breugelmans, M; Moss, CX; Rudolf, J; Cos, P; Coombs, GH; Maes, L; Haemers, A; Mottram, JC; Augustyns, K Design and evaluation of Trypanosoma brucei metacaspase inhibitors. Bioorg Med Chem Lett 20:2001-6 (2010) [PubMed] Article
More Info.:
Target
Name:
Metacaspase-2
Synonyms:
Metacaspase
Type:
PROTEIN
Mol. Mass.:
37791.17
Organism:
Trypanosoma brucei
Description:
ChEMBL_614949
Residue:
347
Sequence:
MCSLITQLCDAGQLADYVGLGWLNAVSSQPYLVQALGLQPPPRRVDVDAAFRDAEGLHGHQPWVATPLPGRTVRALFIGINYYGTSAALSGCCNDVKQMLATLQKKGLPINEAVILVDEDNFPGRTDQPTRDNIVRYMAWLVKDAKPGDVLFFHYSGHGTQCKSRGDSDEKYDQCIAPVDFQKSGCIVDDDIHKLLFSRLPEKVRLTAVFDCCHSGSIMDLPFTYVCSGGEQASGTPHMKRIREGNDVLGDVMMISGCADEQTSADVKNTATFGTGSTGAGGAATQCITCMLMNNQSLSYGKLLIETRDMLKRKGFKQVPQLSASKAIDLDQTFSLTEMFSVDRSVQ
Inhibitor
Name:
BDBM14297
Synonyms:
US10676470, Compound 23 | US11332464, Compound 23 | US9988375, Compound 23 | benzthiazole analog 1 | benzyl N-[(2S)-6-amino-1-(1,3-benzothiazol-2-yl)-1-oxohexan-2-yl]carbamate
Type:
Small organic molecule
Emp. Form.:
C21H23N3O3S
Mol. Mass.:
397.491
SMILES:
NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1nc2ccccc2s1 |r|