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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50315137
Substrate
n/a
Meas. Tech.
ChEMBL_624942 (CHEMBL1107065)
EC50
>10000±n/a nM
Citation
 Wu, Y; Kuntz, JD; Carpenter, AJ; Fang, J; Sauls, HR; Gomez, DJ; Ammala, C; Xu, Y; Hart, S; Tadepalli, S 2,5-Disubstituted pyridines as potent GPR119 agonists. Bioorg Med Chem Lett 20:2577-81 (2010) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50315137
Synonyms:
CHEMBL1088915 | isopropyl 4-((6-(4-(dimethylcarbamoyl)piperazin-1-yl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H35N5O4
Mol. Mass.:
433.5444
SMILES:
CC(C)OC(=O)N1CCC(COc2ccc(nc2)N2CCN(CC2)C(=O)N(C)C)CC1
Structure:
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