Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50315164
Substrate
n/a
Meas. Tech.
ChEMBL_624942 (CHEMBL1107065)
EC50
700±n/a nM
Citation
 Wu, Y; Kuntz, JD; Carpenter, AJ; Fang, J; Sauls, HR; Gomez, DJ; Ammala, C; Xu, Y; Hart, S; Tadepalli, S 2,5-Disubstituted pyridines as potent GPR119 agonists. Bioorg Med Chem Lett 20:2577-81 (2010) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50315164
Synonyms:
CHEMBL1093453 | isopropyl 4-(2-(6-(4-(propylsulfonyl)piperazin-1-yl)pyridin-3-yloxy)ethyl)piperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C23H38N4O5S
Mol. Mass.:
482.637
SMILES:
CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCCC2CCN(CC2)C(=O)OC(C)C)cn1
Structure:
Search PDB for entries with ligand similarity: