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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50316331
Substrate
n/a
Meas. Tech.
ChEMBL_627831 (CHEMBL1117208)
Ki
710±n/a nM
Citation
 Czopek, A; Byrtus, H; Kolaczkowski, M; Pawlowski, M; Dybala, M; Nowak, G; Tatarczynska, E; Wesolowska, A; Chojnacka-Wójcik, E Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT1A receptor agonist with potential antidepressant and anxiolytic activity. Eur J Med Chem 45:1295-303 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM50316331
Synonyms:
CHEMBL1098616 | rac-5-Cyclopropyl-5-phenyl-3-{3-[4-(2-methoxyphenyl)piperazin-1-y]propyl}¿¿¿¿¿imidazolidine-2,4-dione
Type:
Small organic molecule
Emp. Form.:
C26H32N4O3
Mol. Mass.:
448.5573
SMILES:
COc1ccccc1N1CCN(CCCN2C(=O)NC(C3CC3)(C2=O)c2ccccc2)CC1
Structure:
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