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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Ligand
BDBM50145371
Substrate
n/a
Meas. Tech.
ChEMBL_631605 (CHEMBL1106599)
IC50
4500±n/a nM
Citation
 Sliman, F; Blairvacq, M; Durieu, E; Meijer, L; Rodrigo, J; Desmaële, D Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett 20:2801-5 (2010) [PubMed]  Article 
Target
Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Synonyms:
DYR1A_MOUSE | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dyrk | Dyrk1a
Type:
PROTEIN
Mol. Mass.:
85526.58
Organism:
Mus musculus
Description:
ChEMBL_631605
Residue:
763
Sequence:
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPSISDQQVSALPYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLAMRQGADREESPMTGVCVQQSPVASS
  
Inhibitor
Name:
BDBM50145371
Synonyms:
2-(2,4-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinoline-7-carboxylic acid | 2-(2,4-dihydroxybenzylcarbamoyl)-8-hydroxyquinoline-7-carboxylic acid | CHEMBL81714
Type:
Small organic molecule
Emp. Form.:
C18H14N2O6
Mol. Mass.:
354.3136
SMILES:
OC(=O)c1ccc2ccc(nc2c1O)C(=O)NCc1ccc(O)cc1O
Structure:
Search PDB for entries with ligand similarity: