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Target
Uracil nucleotide/cysteinyl leukotriene receptor
Ligand
BDBM50318029
Substrate
n/a
Meas. Tech.
ChEMBL_631134 (CHEMBL1107398)
IC50
508±n/a nM
Citation
 Calleri, E; Ceruti, S; Cristalli, G; Martini, C; Temporini, C; Parravicini, C; Volpini, R; Daniele, S; Caccialanza, G; Lecca, D; Lambertucci, C; Trincavelli, ML; Marucci, G; Wainer, IW; Ranghino, G; Fantucci, P; Abbracchio, MP; Massolini, G Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor. J Med Chem 53:3489-501 (2010) [PubMed]  Article 
Target
Name:
Uracil nucleotide/cysteinyl leukotriene receptor
Synonyms:
GPR17 | GPR17_HUMAN
Type:
PROTEIN
Mol. Mass.:
41013.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1353471
Residue:
367
Sequence:
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
  
Inhibitor
Name:
BDBM50318029
Synonyms:
CHEMBL1096400 | diammonium (2R,3S,5R)-2-[(hydrogen phosphonatooxy)methyl]-5-[6-(methylamino)-9H-purin-9-yl]oxolan-3-yl hydrogen phosphate
Type:
Small organic molecule
Emp. Form.:
C11H17N5O9P2
Mol. Mass.:
425.2283
SMILES:
CNc1ncnc2n(cnc12)[C@H]1C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1 |r|
Structure:
Search PDB for entries with ligand similarity: