Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM7461
Substrate
n/a
Meas. Tech.
ChEMBL_631366 (CHEMBL1109118)
IC50
7790±n/a nM
Citation
 Zou, XQ; Peng, SM; Hu, CP; Tan, LF; Yuan, Q; Deng, HW; Li, YJ Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin. Bioorg Med Chem 18:3020-5 (2010) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM7461
Synonyms:
5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihydroxy-2-phenyl-chromen-4-one | 5,7-dihydroxyflavone | CHEMBL117 | chrysin | cid_5281607
Type:
Small organic molecule
Emp. Form.:
C15H10O4
Mol. Mass.:
254.2375
SMILES:
Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1
Structure:
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