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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50101858
Substrate
n/a
Meas. Tech.
ChEMBL_633614 (CHEMBL1117757)
Ki
0.7±n/a nM
Citation
 Allen, JG; Fotsch, C; Babij, P Emerging targets in osteoporosis disease modification. J Med Chem 53:4332-53 (2010) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_MOUSE | PGE receptor, EP4 subtype | Prostanoid EP4 receptor | Ptger4 | Ptgerep4
Type:
G-protein coupled receptor
Mol. Mass.:
56175.66
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
513
Sequence:
MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI
  
Inhibitor
Name:
BDBM50101858
Synonyms:
4-(2-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxy-4-(3-(methoxymethyl)phenyl)but-1-enyl)-5-oxocyclopentyl)ethylthio)butanoic acid | 4-(2-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-ethylsulfanyl)-butyric acid | CHEMBL292964
Type:
Small organic molecule
Emp. Form.:
C23H32O6S
Mol. Mass.:
436.562
SMILES:
COCc1cccc(C[C@H](O)\C=C\[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(O)=O)c1
Structure:
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