Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM50318880
Substrate
n/a
Meas. Tech.
ChEMBL_633322 (CHEMBL1120161)
IC50
58±n/a nM
Citation
 Allen, JG; Fotsch, C; Babij, P Emerging targets in osteoporosis disease modification. J Med Chem 53:4332-53 (2010) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_RAT | Ctsk
Type:
PROTEIN
Mol. Mass.:
36798.82
Organism:
Rattus norvegicus
Description:
ChEMBL_633322
Residue:
329
Sequence:
MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFPKM
  
Inhibitor
Name:
BDBM50318880
Synonyms:
(S)-2-(4-(2-(1-(biphenyl-3-ylamino)cyclohexanecarboxamido)butylamino)phenoxy)acetic acid | CHEMBL1083675
Type:
Small organic molecule
Emp. Form.:
C31H37N3O4
Mol. Mass.:
515.6432
SMILES:
CC[C@@H](CNc1ccc(OCC(O)=O)cc1)NC(=O)C1(CCCCC1)Nc1cccc(c1)-c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: