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Target
Ecdysone receptor
Ligand
BDBM50326758
Substrate
n/a
Meas. Tech.
ChEMBL_661762 (CHEMBL1251995)
IC50
8500±n/a nM
Citation
 Birru, W; Fernley, RT; Graham, LD; Grusovin, J; Hill, RJ; Hofmann, A; Howell, L; James, PJ; Jarvis, KE; Johnson, WM; Jones, DA; Leitner, C; Liepa, AJ; Lovrecz, GO; Lu, L; Nearn, RH; O'Driscoll, BJ; Phan, T; Pollard, M; Turner, KA; Winkler, DA Synthesis, binding and bioactivity of gamma-methylene gamma-lactam ecdysone receptor ligands: advantages of QSAR models for flexible receptors. Bioorg Med Chem 18:5647-60 (2010) [PubMed]  Article 
Target
Name:
Ecdysone receptor
Synonyms:
20-hydroxy-ecdysone receptor | 20E receptor | ECR_LUCCU | EcR | EcRH | Ecdysteroid receptor | NR1H1 | Nuclear receptor subfamily 1 group H member 1
Type:
PROTEIN
Mol. Mass.:
82587.92
Organism:
Lucilia cuprina
Description:
ChEMBL_661762
Residue:
757
Sequence:
MMKRRWSNNGGFAALKMLEESSSEVTSSSNGLVLSSDINMSPSSLDSPVYGDQEMWLCNDSASYNNSHQHSVITSLQGCTSSLPAQTTIIPLSALPNSNNASLNNQNQNYQNGNSMNTNLSVNTNNSVGGGGGGGGVPGMTSLNGLGGGGGSQVNNHNHSHNHLHHNSNSNHSNSSSHHTNGHMGIGGGGGGLSVNINGPNIVSNAQQLNSLQASQNGQVIHANIGIHSIISNGLNHHHHHHMNNSSMMHHTPRSESANSISSGRDDLSPSSSLNGFSTSDASDVKKIKKGPAPRLQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYCCKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKIQTSVCATEIKKEILDLMTCEPPSHPTCPLLPEDILAKCQARNIPPLSYNQLAVIYKLIWYQDGYEQPSEEDLKRIMSSPDENESQHDASFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHNSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMYSMKVDNVEYALLTAIVIFSDRPGLEEAELVEAIQSYYIDTLRIYILNRHCGDPMSLVFFAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSVQSHIQATQAEKAAQEAQATTSAISAAATSSSSINTSMATSSSSSLSPSAASTPNGGAVDYVGTDMSMSLVQSDNA
  
Inhibitor
Name:
BDBM50326758
Synonyms:
1-(4-tert-butyl-2,5-dichlorophenyl)-4-methyl-5-methylene-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile | CHEMBL1254453
Type:
Small organic molecule
Emp. Form.:
C17H16Cl2N2O
Mol. Mass.:
335.228
SMILES:
CC1=C(C#N)C(=O)N(C1=C)c1cc(Cl)c(cc1Cl)C(C)(C)C |c:1|
Structure:
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