Reaction Details
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1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Ligand
BDBM50155470
Substrate
n/a
Meas. Tech.
ChEMBL_662817 (CHEMBL1252217)
IC50
2100±n/a nM
Citation
Aboraia, AS; Makowski, B; Bahja, A; Prosser, D; Brancale, A; Jones, G; Simons, C Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones. Eur J Med Chem 45:4427-34 (2010) [PubMed] Article More Info.:
Target
Name:
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Synonyms:
CP24A_RAT | Cyp24 | Cyp24a1 | Cytochrome P450 24A1
Type:
PROTEIN
Mol. Mass.:
59467.61
Organism:
Rattus norvegicus
Description:
ChEMBL_305549
Residue:
514
Sequence:
MSCPIDKRRTLIAFLRRLRDLGQPPRSVTSKASASRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR
Inhibitor
Name:
BDBM50155470
Synonyms:
2-biphenyl-2-ylmethyl-6-hydroxy-3,4-dihydro-2H-naphthalen-1-one | CHEMBL361073
Type:
Small organic molecule
Emp. Form.:
C23H20O2
Mol. Mass.:
328.4037
SMILES:
Oc1ccc2C(=O)C(Cc3ccccc3-c3ccccc3)CCc2c1
Structure:
