Reaction Details Report a problem with these data
Target
Sterol 26-hydroxylase, mitochondrial
Ligand
BDBM50155468
Substrate
n/a
Meas. Tech.
ChEMBL_662819 (CHEMBL1252219)
IC50
4330±n/a nM
Citation
Aboraia, AS; Makowski, B; Bahja, A; Prosser, D; Brancale, A; Jones, G; Simons, C Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones. Eur J Med Chem 45:4427-34 (2010) [PubMed] Article
More Info.:
Target
Name:
Sterol 26-hydroxylase, mitochondrial
Synonyms:
CP27A_HUMAN | CYP27 | CYP27A1
Type:
PROTEIN
Mol. Mass.:
60250.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_430507
Residue:
531
Sequence:
MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAPGAGPGVRRRQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQRQC
Inhibitor
Name:
BDBM50155468
Synonyms:
2-[1-(2-Bromo-phenyl)-meth-(E)-ylidene]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one | 2-[1-(2-bromophenyl)methylidene]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one | CHEMBL363682
Type:
Small organic molecule
Emp. Form.:
C18H15BrO2
Mol. Mass.:
343.215
SMILES:
COc1ccc2C(=O)\C(CCc2c1)=C\c1ccccc1Br