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Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50327640
Substrate
n/a
Meas. Tech.
ChEMBL_664981 (CHEMBL1259938)
EC50
2400±n/a nM
Citation
 Bridges, TM; Kennedy, JP; Hopkins, CR; Conn, PJ; Lindsley, CW Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg Med Chem Lett 20:5617-22 (2010) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_HUMAN | CHRM5
Type:
PROTEIN
Mol. Mass.:
60102.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517990
Residue:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50327640
Synonyms:
1-((6-chloropyridin-3-yl)methyl)-5-(trifluoromethoxy)indoline-2,3-dione | CHEMBL1257499
Type:
Small organic molecule
Emp. Form.:
C15H8ClF3N2O3
Mol. Mass.:
356.684
SMILES:
FC(F)(F)Oc1ccc2N(Cc3ccc(Cl)nc3)C(=O)C(=O)c2c1
Structure:
Search PDB for entries with ligand similarity: