Reaction Details Report a problem with these data
Target
Malonyl-CoA decarboxylase, mitochondrial
Ligand
BDBM50328249
Substrate
n/a
Meas. Tech.
ChEMBL_665404 (CHEMBL1261133)
IC50
3.3±n/a nM
Citation
Tang, H; Yan, Y; Feng, Z; de Jesus, RK; Yang, L; Levorse, DA; Owens, KA; Akiyama, TE; Bergeron, R; Castriota, GA; Doebber, TW; Ellsworth, KP; Lassman, ME; Li, C; Wu, MS; Zhang, BB; Chapman, KT; Mills, SG; Berger, JP; Pasternak, A Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorg Med Chem Lett 20:6088-92 (2010) [PubMed] Article
More Info.:
Target
Name:
Malonyl-CoA decarboxylase, mitochondrial
Synonyms:
DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase
Type:
PROTEIN
Mol. Mass.:
55018.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_665404
Residue:
493
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
Inhibitor
Name:
BDBM50328249
Synonyms:
1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)thiazol-2-yl)-4-phenyl-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide | CHEMBL1258368
Type:
Small organic molecule
Emp. Form.:
C20H18F9N3O2S
Mol. Mass.:
535.426
SMILES:
OC(c1cnc(s1)N1CCC(CC1)(C(=O)NCC(F)(F)F)c1ccccc1)(C(F)(F)F)C(F)(F)F